STIM1 and Orai1: novel targets for vascular diseases?
نویسندگان
چکیده
منابع مشابه
STIM1 and Orai in cardiac hypertrophy and vascular proliferative diseases.
Cardiac hypertrophy and vascular proliferative diseases are associated with major alterations in calcium homeostasis and calcium signaling. The recent discovery of STIM and Orai has generated great enthusiasm concerning the role of these proteins in the cardiovascular system. We will review the major results concerning the existence and the role of these proteins in the cardiovascular system in...
متن کاملOrai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes.
Cardiac hypertrophy is an independent risk for heart failure (HF) and sudden death. Deciphering signalling pathways dependent on extracellular calcium (Ca(2+)) influx that control normal and pathological cardiac growth may enable identification of novel therapeutic targets. The objective of the present study is to determine the role of the Ca(2+) release-activated Ca(2+) (CRAC) channel Orai1 an...
متن کاملSTIM1/Orai1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats.
Sex differences in Ca2+-dependent signalling and homoeostasis in the vasculature of hypertensive rats are well characterized. However, sex-related differences in SOCE (store-operated Ca2+ entry) have been minimally investigated. We hypothesized that vascular protection in females, compared with males, reflects decreased Ca2+ mobilization due to diminished activation of Orai1/STIM1 (stromal inte...
متن کاملImmunodeficiency due to mutations in ORAI1 and STIM1.
Lymphocyte activation requires Ca(2+) influx through specialized Ca(2+) channels in the plasma membrane. In T cells the predominant Ca(2+) channel is the Ca(2+) release activated Ca(2+) (CRAC) channel encoded by the gene ORAI1. ORAI1 is activated by stromal interaction molecule (STIM) 1 that is localized in the ER where it senses the concentration of stored Ca(2+). Following antigen binding to ...
متن کاملA cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions
STIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER). The series of molecular rearrangements that STIM1 undergoes until final activation of Orai1 require the direct exposure of the S...
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ژورنال
عنوان ژورنال: Science China Life Sciences
سال: 2011
ISSN: 1674-7305,1869-1889
DOI: 10.1007/s11427-011-4206-6